[DOI] [PubMed] [Google Scholar] 113.Sellmann C., Baumann A., Brandt A., Jin C.J., Nier A., Bergheim I
Structural and functional characterization of GS from bacteria demonstrates that this enzyme functions as a tetramer (Yamaguchi et al., Arabidopsis , wheat ( Triticum aestivum ), maize ( Zea mays ), and various legumes share ~40% amino acid sequence identity with the human and yeast homologs (Rawlins et al., Early mutagenesis studies of the Arabidopsis GS identified a putative glycine-rich loop as important for activity (Wang and Oliver, Arabidopsis GS uses a random Ter-reactant mechanism with binding of either ATP or -glutamylcysteine preferred first and addition of glycine last (Jez and Cahoon, Arabidopsis GS and for the eukaryotic homologs (Herrera et al., 2+ to ATP and orienting the -phosphate group in the active site
The lack of universal dosing protocols, as well as abuse outside of medical supervision, work to heighten these issues of safety
Glutathione also helps with detoxification by supporting the removal of toxins